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Since the MEE algorithm allows the reduced requirement of the number of data points for small size experimentation, and yields quantitative bioinformatics, it points to the deterministic, efficient, low-cost biomedical research and drug discovery, and ethical planning for clinical trials. (1996) CalcuSyn Windows Software for Dose Effect Analysis, Biosoft.
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Its applications include the construction of a dose-effect curve with a theoretical minimum of only two data points if they are accurately determined quantification of synergism or antagonism at all dose and effect levels the low-dose risk assessment for carcinogens, toxic substances or radiation and the determination of competitiveness and exclusivity for receptor binding. We focus this review on application of the Combination Index method (as. The “median” is the universal common-link and reference-point for the 1st-order to higher-order dynamics, and from single-entities to multiple-entities and thus, it allows the all for one and one for all unity theory to “integrate” simple and complex systems. Rearrangement of MEE yields the mathematical form of the Michaelis–Menten, Hill, Henderson–Hasselbalch and Scatchard equations of biochemistry and biophysics, and the median-effect plot allows linearization of all dose-effect curves regardless of potency and shape. Specific examples of the theoretical equations, the median-effect plot, the CI plot, the isobologram, and the polygonogram are illustrated.The relationship between dose and effect is not random, but rather governed by the unified theory based on the median- effect equation (MEE) of the mass-action law. CalcuSyn: windows software for dose effect analysis. analysis of multiple drug effects (Tallarida 2OO2). 47:119-122, 1987) and combination of immunosuppressants for organs transplants. The purpose of this study was to employ the anti-proliferative effects of the hexadentate iron. Dose-mortality regression lines were determined for each insecticide. Drug potency (IC50) and steepness (m) of the doseresponse curves obtained after. Chou TC and Hayball MP: CalcuSyn for Windows: multiple-drug dose effect. Please bear in mind that the use of the software might be restricted in terms of time or functionality.
#CALCUSYN WINDOWS SOFTWARE FOR DOSE EFFECT ANALYSIS DOWNLOAD#
The contents of the download are original and were not modified in any way. This method has been applied in combination of anticancer agents, anti-HIV agents, purging leukemic cells for autologous bone marrow transplantation (Chang et al. data were analyzed by the CalcuSyn software, which is based. The version of CalcuSyn you are about to download is 2.1. The Chou-Talalay method distincts from all other methods by the fact that it not only takes into account the "potency" but also the "shape" of dose-effect curves of each drug and their combinations (Chou & Hayball, CalcuSyn for Windows, Biosoft, Cambridge UK, 1996).
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Dose reduction leads to reduced toxicity while maintaining the desired efficacy (Chou et al. The user-friendly computer program also gives dose-reduction index (DRI) which determines how many fold of dose-reduction is allowed for each drug in synergistic combinations. These analyses has been shown to be useful for the clinical protocol design. Therefore, it allows the selection of the best pair (or triplet) of combination, optimal combination ratio, and the best schedule of treatment. This method provides quantitation of synergism (CI 1) at different dose and effect levels. CalcuSyn windows software for dose effect analysis. Analysis of combined drug effects: a new look at a very old problem. A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems. Based on the median-effect equation of Chou and the combination index (CI) equation of Chou-Talalay, a computer software for automated dose-effect analysis has been developed. dependent reduction in the expression levels of anti-apoptotic Bcl-2 family members were. CalcuSyn, Windows software for dose effect analysis.